Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests

Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery

Objective(s): The purpose of this study was preparation and evaluation of PVA-Fe3O4 nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values. Methods: Fe3O4 nanoparticles were synthesized by coprecipitation...

Novel Delivery System for Minimally Invasive MR Guided Neurological Interventions

Introduction The delivery of electrodes or other therapeutic agents to the brain frequently requires precision minimally invasive access. MR is ideally suited to this application and high targeting accuracies have been reported when delivering deep brain stimulator (DBS) electrodes (1). Convection enhanced delivery (CED) is a promising technique for delivering drug and gene therapies to the bra...

Magnetic/pH-sensitive nanocomposite hydrogel based carboxymethyl cellulose –g- polyacrylamide/montmorillonite for colon targeted drug delivery

Objective(s): The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N,N'-methylene bis acrylamide  (MBA)  as a crosslinking agent, potassium persulfate (KPS) as a free radical initiator, and  magnetic montmorillonite ( mMT)  nanoclay as nano-...

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned...

Advances in Targeted Drug Delivery